Genetic Testing For Alzheimer's Risk

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(APOE test)

If you had a family history of developing Alzheimer's disease, would you take a genetic test that would give you more information about your chances? 

"Definitely," said Gloria VanAlstine, 60, and Joyce Smith, 79. The two women took a controversial genetic test of a gene called Apolipoprotein E. APOE is a susceptibility gene where certain variants have been found to significantly increase a person's risk of developing Alzheimer's disease. Both women have a family history of Alzheimer's, which increases risk. 

The genetic test was conducted as part of the Risk Evaluation and Education for Alzheimer's disease Study (REVEAL), a series of clinical trials taking place at U-M School of Public Health, with other sites including Harvard University, Howard University, and the University of Pennsylvania. 

APOE testing is controversial in the medical community because the variant is neither necessary nor sufficient to cause Alzheimer's disease. This limitation, along a with a general lack of treatment options for Alzheimer's, has raised concerns that the genetic information could burden rather than benefit patients. There have been numerous consensus statements and articles against using APOE genotyping for predicting Alzheimer's risk. Continue to read: medilexicon.com

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