Statins May be Beneficial in Treating Alzheimer's Disease

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(statin for 18 months)

Prior research studies have suggested certain cholesterol lowering statin drugs may not have beneficial effects on patients with Alzheimer's Disease (AD). In fact in a study where patients were treated with simvastatin for 18 months, compared with those who were administered placebo, patients were shown not to exhibit any benefit in lowering cholesterol, a risk factor that can be seen as beneficial in patients with AD. Patients with Mini Mental State Examination (MMSE) scores between 12-28 were recruited. The study aimed to positively influence a series of outcome measures that may suggest improvement in the trial participants. Sparks looked at specific outcome measurements to assess patient benefit of atorvastatin use.  Primary outcome measures used were: changes in the Alzheimer's Disease Assessment Scale-cognitive subscale and the Clinical Global Impression of Change Scale Scores. Other outcome measures focused on MMSE scores, Geriatric Depression Scale scores, Neuropsychiatric Inventory Scale, cholesterol levels and the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory. 

Results of the study showed benefit in cognition and other outcome measures following atorvastatin treatment which achieved statistical significance compared with placebo at six months and patients treated with the statin showed a trend towards improvement at one year. "This evidence may be of clinical benefit to patients and could be established as a possible effective treatment for patients suffering from AD," says Sparks. "While these findings are provocative, larger research trials are required to further research the significance of statins as a treatment for AD.".Continue to read: sys-con.com

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Fish consumption reduced risk for Alzheimer’s disease

People who eat baked or broiled fish on a weekly basis may be improving their brain health and reducing their risk of developing mild cognitive impairment and Alzheimer's disease, according to a study presented atA an annual meeting of the Radiological Society of North America. Read more: detroit.cbslocal.com

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