20 Things To Know About Alzheimer's Disease

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Alzheimer's facts

( loss of sacsin causing network to become interconnected )

A devastating neurodegenerative disease that first appears in toddlers just as they are beginning to walk has been traced to defects in mitochondria, the 'batteries' or energy-producing power plants of cells. This finding by researchers at Queen Mary, University of London and Montreal Neurological Institute and Hospital - The Neuro - at McGill University, is published in this week's issue of the Proceedings of the National Academy of Sciences of the USA.

The disorder, Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS), primarily affects the cerebellum, a center for movement coordination in the brain. It was first identified in the late 1970s in a large group of patients from Quebec in Canada.

ARSACS strikes at an early age. Symptoms, which worsen over time, include poor motor coordination, spastic stiffness, distal muscle wasting, uncoordinated eye movements and slurred speech. Most patients with the disease are wheelchair-bound by their early 40s and have a reduced life expectancy. ARSACS is not unique to French-Canada as scientists have now found over 100 separate mutations in people worldwide including, including patients in the UK. Continue to read: medicalnewstoday.com

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