Monday, January 30, 2012

Protein could create amyloid beta

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(  12/15-Lipoxygenase is a controller of BACE functions )
A protein recently discovered in the brain could play a key role in regulating the creation of amyloid beta, the major component of plaques implicated in the development of Alzheimer’s disease, according to researchers at Temple University’s School of Medicine.
A group led by Domenico Pratico, professor of pharmacology and microbiology and immunology at Temple, discovered the presence of the protein, called 12/15-Lipoxygenase, in the brain three years ago. Following two years of study, the Temple researchers have found that the protein is at the top of a pathway and controls a biochemical chain reaction that begins the development of Alzheimer’s. They have published their findings, “Transcriptional Regulation of ßsecretase-1 by 12/15 Lipoxygenase Results in Enhanced Amyloidogenesis and Cognitive Impairments,” in the journal Annals of Neurology.
Pratico said that their research has shown that 12/15-Lipoxygenase controls Beta secretase (BACE-1), an enzyme that is key to the development of amyloid plaques in Alzheimer’s patients. Continue to read: jpost.com


Green tea may reduce functional disability risk


Consuming at least five cups of green tea per day may reduce the risk of functional disabilities like osteoporosis and stroke, suggests new data from Japan. Read more: nutraingredients-usa.com 

Погода в Беларуси


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