Monday, March 5, 2012

Promising approach to interrupting Alzheimer's

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(  finding various ways to block BACE1 )
More than five million people in the United State may have Alzheimer's, a complicated disease that has been a challenge to understand. Many researchers have zeroed in on amyloid, which accumulates in the brains of patients with Alzheimer's, as one of the main culprits.
Amyloid originates from a protein called amyloid precursor protein, or APP. An enzyme called beta-site APP cleaving enzyme, or BACE1, cuts APP to produce amyloid and another small fragment called AICD. Both amyloid and AICD are toxic to nerve cells and have been linked to AD.
The current research, under the direction of Dr. Luigi Puglielli, associate professor of medicine at the UW School of Medicine and Public Health (SMPH), centers generally on BACE1. Elevated levels of this enzyme, which rise normally during aging, may lead to high levels of amyloid.
"The prediction is that if you prevent the up-regulation of BACE1 caused by aging, you could prevent the increased risk of Alzheimer's disease that is also associated with aging," says Puglielli, of the Geriatric Research and Education Center at the William S. Middleton Memorial Veterans Hospital in Madison. Continue to read: sciencedaily.com


Read more here: http://www.bnd.com/2012/02/07/2047945/obama-to-seek-more-alzheimers.html#storylink=cpy


Curcumin has been used as medicine for thousands of years


Curcumin, a substance extracted from turmeric, prolongs life and enhances activity of fruit flies with a nervous disorder similar to Alzheimers, according to new research. Read more:  sciencedaily.com

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