Alzheimer's and clearance amyloid protein from brain
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Instead of producing too much of a protein, people with Alzheimer's disease appear to have trouble getting rid of it, U.S. researchers said on Thursday. The finding, published in the journal Science, may help explain why people with Alzheimer's accumulate sticky clumps of a protein called amyloid beta, and it may help drug companies hone in on potential treatments. "In people who have Alzheimer's disease, we know there are very large amounts of amyloid beta in the brain," said Dr. Randall Bateman of Washington University in St. Louis, who worked on the study.
Bateman said in a telephone interview people with Alzheimer's disease have between 100 and 1,000 times the normal amount of amyloid in their brains. "The question was, 'How did all of that get there?'" He said the brain normally makes amyloid beta, so the team compared the rate at which the brain produced and got rid of amyloid beta in 12 people with Alzheimer's disease and 12 healthy people.
They found no difference in the levels of amyloid produced by either group, but they found a 30 percent reduction in the rate at which Alzheimer patients cleared the protein from the brain. Read more: reuters.com
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