Early treatment for Alzheimer's disease

( focus on the more typical form of late-onset )

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An Arizona research group has established an ambitious target: to treat Alzheimer's disease before symptoms appear. The Alzheimer's Prevention Initiative, orchestrated by the scientists from Banner Alzheimer's Institute, is pursuing that goal with the launch of two large studies that organizers say could spur a new era of Alzheimer's research.
One study will focus on as many as 5,000 people from about two dozen extended families in Colombia. An estimated 40 percent carry a genetic mutation linked to early-onset Alzheimer's disease, with some individuals developing the memory-robbing disease in their 40s.
The second part of the study will include a heavy Arizona focus, recruiting as many as 400 volunteers between the ages of 60 and 80 from the Phoenix area and elsewhere who carry two copies of an Alzheimer's susceptibility gene called APOE4. A person with two copies of the aberrant gene has a higher risk of developing the disease.
Study organizers plan to administer treatment to the two groups and evaluate whether therapies have the ability to halt or slow the disease before symptoms appear. The Alzheimer's Prevention Initiative wants to test whether drugs or vaccines can potentially postpone the onset, reduce the risk of acquiring or halt the disease altogether. "We believe now is the time to launch the era of Alzheimer's prevention research," said Dr. Eric Reiman, executive director of Phoenix-based Banner Alzheimer's Institute. "Our long-standing interest has been accelerating the evaluation of promising, pre-symptomatic Alzheimer's treatments before the onset of symptoms." Read more: azcentral.com

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How to manage your arthritis

Excess weight gain, overuse of joints, injuries, infections, female hormones, stress, diet and smoking – all of these may play a part in the disease. The two most common types are osteoarthritis and rheumatoid arthritis. Both can be immensely debilitating and often have similar symptoms – pain, stiffness and limited movement. Although there are a number of ways to treat and manage arthritis, most experts agree that eating a balanced diet and maintaining a healthy weight are the best ways to keep joints in good condition. Here are eight ways to take control and keep arthritis at bay. Read more: dailymail.co.uk

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