New Era of Genetic Studies for Alzheimer's

( the associations between genes and neuroimaging results )

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"While we have understood the bases for mendelian, early-onset Alzheimer's disease for nearly two decades, elucidation of the genetic risks for late-onset disease beyond the apolipoprotein E locus, discovered in 1993, had been painfully slow until last year," write John Hardy, Ph.D., of University College London Institute of Neurology, and Julie Williams, Ph.D., of the Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, Wales, in an accompanying editorial.
"With the benefit of hindsight, we now have some indication of why no other risk loci were found during this period; simply, there are no other loci with similar effect sizes to apolipoprotein E to be found. Now, however, with the advent of whole-genome associations, we are beginning to find the weaker risk loci for the disease."
"These findings, and the genome-wide studies that presaged them, mark a new period of optimism for those of us who study the etiologies of complex diseases of the nervous system," Drs. Hardy and Williams write. "While the drought of genetic findings in Alzheimer's disease has lasted a long time, the flood of new findings have been a reward worth waiting for." Read more:  sciencedaily.com

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