Protective Effect of Resveratrol on Neurodegeneration

( beneficial effects of resveratrol and grape polyphenols )

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Resveratrol is present in a variety of plants including vegetables, fruits, grains, roots, flowers, seeds, tea, and wine. It has been shown to offer protective effects against a number of cardiovascular and neurodegenerative diseases, and cancer. Although the mechanisms by which resveratrol exerts such a wide range of beneficial effects on these diseases have not yet been clearly elucidated, a number of studies have reported on its antioxidant, anti-inflammatory, and metal-chelating properties. Excess production of reactive oxygen species in the brain has been implicated as a common underlying risk factor for the pathogenesis of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In recent years, there is considerable interest concerning investigation of antioxidative and anti-inflammatory effects of phenolic compounds from different botanical sources. In this review, we first describe oxidative mechanisms associated with stroke, AD, and PD, and subsequently, we place emphasis on recent studies implicating neuroprotective effects of resveratrol, a polyphenolic compound derived from grapes and red wine. These studies show that the beneficial effects of resveratrol are not only limited to its antioxidant and anti-inflammatory action but also include activation of sirtuin 1 (SIRT1) and vitagenes, which can prevent the deleterious effects triggered by oxidative stress. In fact, SIRT1 activation by resveratrol is gaining importance in the development of innovative treatment strategies for stroke and other neurodegenerative disorders. The goal here is to provide a better understanding of the mode of action of resveratrol and its possible use as a potential therapeutic agent to ameliorate stroke damage as well as other age-related neurodegenerative disorders. Read more: springerlink.com

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Resveratrol – a compound in red wine - may be influencing both blood vessel function and the function of fat cells, say new studies which may help explain its heart health benefits. Read more: nutraingredients.com

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