A screening method for potential drugs for Alzheimer's
(tangled fibrils and plaques in the brains)
(tangled fibrils and plaques in the brains)
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Brain cells exposed to a form of the amyloid beta protein, the molecule linked to Alzheimer's disease, become stiffer and bend less under pressure, researchers at UC Davis have found. The results reveal one mechanism by which the amyloid protein damages the brain, a finding that could lead to new ways to screen drugs for Alzheimer's and similar diseases.
The microscope, located at UC Davis' Spectral Imaging Facility, combines an atomic force microscope and a confocal microscope. It is one of a handful in the United States and one of the most advanced of its type, Liu said.
An atomic force microscope uses a fine needle to visualize the features of a surface with exquisite resolution and precision; it is used more often in materials science than in cellular biology. A confocal microscope can view living cells in culture media and in three dimensions.
The team put a glass microbead on the tip of the AFM needle and used it to press down on living cells. By measuring the forces required to squeeze the cell under the bead, they could calculate the stiffness of both the cell membrane and the cell contents.
Read more: sciencedaily.com
The microscope, located at UC Davis' Spectral Imaging Facility, combines an atomic force microscope and a confocal microscope. It is one of a handful in the United States and one of the most advanced of its type, Liu said.
An atomic force microscope uses a fine needle to visualize the features of a surface with exquisite resolution and precision; it is used more often in materials science than in cellular biology. A confocal microscope can view living cells in culture media and in three dimensions.
The team put a glass microbead on the tip of the AFM needle and used it to press down on living cells. By measuring the forces required to squeeze the cell under the bead, they could calculate the stiffness of both the cell membrane and the cell contents.
Read more: sciencedaily.com
Vitamin D disease role
Vitamin D has a significant effect on at least 229 genes some of which have been associated with Crohn’s disease and type 1 diabetes, according to UK and Canadian researchers. Read more: nutraingredients.com
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