Pyridinones as AD therapeutics
(drug design)
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A new treatment for Alzheimer's disease has been developed by Canadian and US scientists.
Chris Orvig at the University of British Columbia, Canada, and colleagues incorporated a thioflavin dye molecule with pyridinones. The dye is used as a marker for detecting amyloid protein deposits in tissues - a sign of neurodegenerative disease - and pyridinones cross the blood-brain barrier and trap the metal ions that cause the Alzheimer's disease.
Alzheimer's affects 24 million people worldwide and is largely caused by increased levels of trace metal ions, such as copper and zinc, in brain tissue. There are few treatments and no cures.
Metal chelation agents that trap metal ions have been used in an effort to reduce the effects of excess metal ions in the brain. But they are limited by poor uptake into brain tissue and poor targeting capabilities. Orvig and his team believe that they now have the answer as a two-pronged attack combining a targeting dye with a metal chelation agent that crosses the blood-brain barrier easily. Read more: rsc.org
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