Protein level: slow or prevent Alzheimer's
(SORL1 network)
Please Help Support Alzheimer's Research Today!
Your Alzheimer's donation will help billions live without it.
Like all cells, neurons use transport proteins to ship cellular components from one region of the cell to another. The shipping process is critical to the production of amyloid beta: transport proteins must carry the amyloid precursor protein (APP) to certain regions of the cell where the protein is processed into soluble forms of amyloid beta.
The new research reveals that a different transport protein, called SORCS1, appears to ferry APP to safe destinations within the cell where it’s sliced into non-toxic pieces instead of amyloid beta.
Alzheimer’s patients appear to express reduced levels of SORCS1 in their brains, Reitz and Mayeux also found, suggesting that APP in patients is more likely to be shipped to cellular compartments that process the protein into toxic amyloid.
Genetic studies included in the paper also show that people who carry certain variants of the SORCS1 gene have a 15 percent greater risk of developing Alzheimer’s.
Taken together, Mayeux says the results show that APP transport proteins are key players in the development of Alzheimer’s disease, especially when considered with similar findings for a related transport protein called SORL1. (The same Columbia and Toronto research group discovered the SORL1 link four years ago). Read more: physorg.com
Taken together, Mayeux says the results show that APP transport proteins are key players in the development of Alzheimer’s disease, especially when considered with similar findings for a related transport protein called SORL1. (The same Columbia and Toronto research group discovered the SORL1 link four years ago). Read more: physorg.com
Good diet fights Alzheimer's
"The main take-away message here is that good diets can alleviate the effects of bad genes. Of course nutritionists have had this general idea for a while, but it's nice to be able to show that this approach can be applied to specifically counteract the negative effects of Alzheimer's disease-related genes," says Prof. Michaelson. Read more: eurekalert.org
No comments:
Post a Comment