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One of the medical challenges with diseases of the brain is getting any treatment to cross the blood-brain barrier, however tests on the brains of mice with Alzheimer's traits, has shown it is possible to use the body's own natural delivery system to get manufactured treatments absorbed by the brain. Currently, less than 5% of drugs (made up of very small molecules) are able to cross the barrier; one example is temozolomide, which is the only chemotherapy available for treating brain tumours such as glioblastoma multiforme and progressive anaplastic astrocytoma. These tumours have a poor prognosis and continue to grow, even after treatment with temozolomide. Therefore, new therapies for these hard-to-treat brain tumours are needed urgently alongside brain malfunctions such as Alzheimer's, Parkinson's and more.
This natural barrier exists to protect the brain, preventing bacteria from crossing over from the blood, while letting oxygen through. However, this has also produced problems for medicine, as drugs can also be blocked. Researchers used the body's own transporters, exosomes, to deliver drugs and proved to be quite successful. The team at Oxford harvested exosomes from mouse dentritic cells, part of the immune system, which naturally produce large numbers of exosomes. They then fused the exosomes with targeting proteins from the rabies virus, which binds to acetylcholine receptors in brain cells, so the exosome would target the brain. Read more: medilexicon.com
This natural barrier exists to protect the brain, preventing bacteria from crossing over from the blood, while letting oxygen through. However, this has also produced problems for medicine, as drugs can also be blocked. Researchers used the body's own transporters, exosomes, to deliver drugs and proved to be quite successful. The team at Oxford harvested exosomes from mouse dentritic cells, part of the immune system, which naturally produce large numbers of exosomes. They then fused the exosomes with targeting proteins from the rabies virus, which binds to acetylcholine receptors in brain cells, so the exosome would target the brain. Read more: medilexicon.com
Eating disorder "orthorexia" and healthy eating
A growing obsession with health eating and food intolerances in the UK has led to an alarming rise in the number of people with the eating disorder 'orthorexia', a leading charity has warned. Read more: dailymail.co.uk
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