Alzheimer's disease: a drug dramatically reduces beta amyloid
( imatinib )
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Results from a Scripps Research Institute and ModGene, LLC study have shattered the fundamental concept of the brain being the source of the amyloid plaque deposits associated with Alzheimer’s disease. The study published online in The Journal of Neuroscience Research suggested that significant concentrations of beta amyloid might originate in the liver, circulate in the blood, and enter the brain. If true, blocking production of beta amyloid in the liver should protect the brain.
In the study, the scientists used a mouse model for Alzheimer’s disease to identify genes that influence the amount of amyloid that accumulates in the brain. They found three genes that protected mice from brain amyloid accumulation and deposition. For each gene, lower expression in the liver protected the mouse brain. One of the genes encodes presenilin — a cell membrane protein believed to contribute to the development of human Alzheimer’s.
“This unexpected finding holds promise for the development of new therapies to fight Alzheimer’s,” said Scripps Research Professor Greg Sutcliffe, who led the study. “This could greatly simplify the challenge of developing therapies and prevention.” Read more: southbendtribune.com
In the study, the scientists used a mouse model for Alzheimer’s disease to identify genes that influence the amount of amyloid that accumulates in the brain. They found three genes that protected mice from brain amyloid accumulation and deposition. For each gene, lower expression in the liver protected the mouse brain. One of the genes encodes presenilin — a cell membrane protein believed to contribute to the development of human Alzheimer’s.
“This unexpected finding holds promise for the development of new therapies to fight Alzheimer’s,” said Scripps Research Professor Greg Sutcliffe, who led the study. “This could greatly simplify the challenge of developing therapies and prevention.” Read more: southbendtribune.com
A few drinks decrease Alzheimer's
Light and moderate drinkers were 29 percent less likely to develop any kind of dementia than people who didn't drink alcohol or who drank high amounts of alcohol, German researchers said. The light and moderate drinkers also had a 42 percent decreased risk of developing Alzheimer's disease, the study said. Read more: msnbc.msn.com
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