Application of market drug against Alzheimer's
( Zileuton )
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Researchers at Temple University's School of Medicine have reported the results of their experiments using an asthma drug, Zileuton, in the treatment of Alzheimer's disease in mouse models. Their discoveries may lead to a major breakthrough in the control and/or treatment of Alzheimer's disease.
In previous studies, Temple researchers found that an enzyme in the brain called 5-lipoxygenase is what activates gamma secretase, the enzyme responsible for the production of amyloid beta - the protein in the brain that, if over-produced, leads to the amyloid plaques associated with Alzheimer's disease.
In the current study, the same researchers attempted to reduce the production of 5-lipoxygenase in a mouse model, using the drug Zileuton (marketed as Zyflo) to pharmacologically intervene in its production, thereby reducing the production of gamma secretase and subsequently the production of amyloid beta. The results were very positive, reducing gamma secretase’s production of amyloid beta and the subsequent build up of amyloid plaques in the brain by more than 50 percent. Read more: inventorspot.com
Probiotics shortened duration of diarrhoea
Probiotics have demonstrated potential to reduce duration of diarrhoea and frequency of watery stools. Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum (Infloran®) are usually maintained at a storage temperature of 4°C which is generally not feasible in tropical or sub-tropical countries. Read more: ncbi.nlm.nih.gov
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