Saturday, November 19, 2011

Early diagnosis for Alzheimer's

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(a multiplex detection array)
US scientists have developed a biosensor that could detect the early stages of Alzheimer's disease (AD) and Parkinson's disease (PD) by measuring low concentrations of protein aggregates in cerebrospinal fluid (CSF). 
Neurodegenerative diseases are challenging to diagnose in the early stages as they have similar symptoms. However, on a cellular level, aggregates of the proteins beta-amyloid and alpha-synuclein have been linked to AD and PD, respectively, and so have been suggested as good biomarkers for each disease. 'Pre-symptomatic diagnosis is a problem,' says lead researcher Shalini Prasad from the University of Texas at Dallas. 'Current diagnostic tests don't have the level of sensitivity and selectivity to detect protein binding. Our goal was to see if we could do both at ultra-low concentrations.'
The biosensor is made up of a printed circuit board overlaid with a porous alumina membrane. The team attached nanobodies (antibody fragments that are specific either for alpha-synuclein aggregates or beta-amyloid aggregates) inside the membrane's pores. When they added CSF to the sensor, the aggregates bound to their specific nanobodies, causing a change in capacitance that was proportional to the aggregates' concentration. Using their sensor, the team measured aggregate levels in CSF samples from people with autopsy-confirmed AD, PD and control samples with no neurodegenerative disease. They found that the sensor could distinguish between the samples based on the protein aggregates present, suggesting that it has potential in the early diagnosis of these diseases. Continue to read: rsc.org


Low fat dairy consumption lowers diabetes risk in postmenopausal women

A diet high in low-fat dairy products is associated with lower diabetes risk in postmenopausal women, particularly those who are obese, according to a new US research study. Read more: nutraingredients.com
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