Risk factors and prevention of Alzheimer's

(no definitive causes)

20 Things To Know About Alzheimer's Disease

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Familial Alzheimer’s disease (FAD) or early-onset Alzheimer’s is an inherited and rare. It affects less than 10 percent of Alzheimer’s disease patients. Familial Alzheimer's disease develops before age 65, in people as young as 35. It is caused by gene mutations on chromosomes 1, 14 and 21. If even one of these mutated genes is inherited from a parent, the person will almost always develop Familial Alzheimer's disease. All offspring in the same generation have a 50/50 chance of developing this type of Alzheimer's if one parent has it.

The majority of Alzheimer’s disease cases are late-onset, usually developing after age 65. Late-onset Alzheimer’s disease has no known cause and shows no obvious inheritance pattern. However, in some families, clusters of cases are seen. Although a specific gene has not been identified as the cause of late-onset Alzheimer’s disease, genetic factors do appear to play a role in the development of this form of the disease. A gene called Apolipoprotein E (ApoE) appears to be a risk factor for the late-onset form of Alzheimer's disease. There are three forms of this gene: ApoE2, ApoE3 and ApoE4. Roughly one in four Americans has ApoE4 and one in twenty has ApoE2. While inheritance of ApoE4 increases the risk of developing Alzheimer's disease, ApoE2 substantially protects against it. Continue to read: watchmojo.com

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