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Up to 12 percent of Americans may get Alzheimer's disease, current statistics say. In the quest to prevent Alzheimer's, or at least make it manageable like diabetes, a group of researchers are working on a nasally-delivered vaccine that promises to protect against Alzheimer's. Bonus: It may help prevent strokes also.
The new vaccine repairs vascular damage in the brain by using the body's own immune system and, in addition to its prophylactic effect, it can work even when Alzheimer's symptoms are already present, according to the paper in Neurobiology of Aging.
"Using part of a drug that was previously tested as an influenza drug, we've managed to successfully induce an immune response against amyloid proteins in the blood vessels," says Dr. Dan Frenkel of Tel Aviv University's Department of Neurobiology, who collaborated on the project with Prof. Howard L. Weiner of Brigham and Women's Hospital, Harvard Medical School. "In early pre-clinical studies, we've found it can prevent both brain tissue damage and restore cognitive impairment," he adds.
Modifying a vaccine technology owned by Glaxo Smith Kline, their approach activates a natural mechanism in our bodies that fights against vascular damage in the brain. The vaccine activates macrophages, large proteins in the body that swallow foreign antigens, and they clear away the damaging build-up of waxy amyloid proteins in our brain's vascular system. Animal models showed that once these proteins are cleared from the brain, further damage can be prevented, and existing damage due to a previous stroke can be repaired. Read more: 100wapi.com
The new vaccine repairs vascular damage in the brain by using the body's own immune system and, in addition to its prophylactic effect, it can work even when Alzheimer's symptoms are already present, according to the paper in Neurobiology of Aging.
"Using part of a drug that was previously tested as an influenza drug, we've managed to successfully induce an immune response against amyloid proteins in the blood vessels," says Dr. Dan Frenkel of Tel Aviv University's Department of Neurobiology, who collaborated on the project with Prof. Howard L. Weiner of Brigham and Women's Hospital, Harvard Medical School. "In early pre-clinical studies, we've found it can prevent both brain tissue damage and restore cognitive impairment," he adds.
Modifying a vaccine technology owned by Glaxo Smith Kline, their approach activates a natural mechanism in our bodies that fights against vascular damage in the brain. The vaccine activates macrophages, large proteins in the body that swallow foreign antigens, and they clear away the damaging build-up of waxy amyloid proteins in our brain's vascular system. Animal models showed that once these proteins are cleared from the brain, further damage can be prevented, and existing damage due to a previous stroke can be repaired. Read more: 100wapi.com
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