To treat moderate-to-severe Alzheimer's

(donepezil HCl)

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According to the Alzheimer's Association, about 3.6 million Americans age 65 and older have moderate-to-severe Alzheimer's disease (AD), which is a degenerative disease of the brain that gets worse over time. By 2050, this number is expected to nearly triple to 10.4 million.

With the growing aging population, it is important to develop treatments that may help patients and their families living with this devastating condition. The U.S. Food and Drug Administration (FDA) recently approved a new once-daily, higher dose Aricept (R)(donepezil HCl) 23 mg tablet, offering a new dosing option for patients with moderate-to-severe AD. In the study of patients with moderate-to-severe AD, cognition was significantly improved in patients taking the Aricept 23 mg tablet versus those taking the Aricept 10 mg tablet, whereas global functioning was not.

"Slowing the decline of cognitive symptoms is important at all stages of Alzheimer's disease," said Dr. Martin R. Farlow, lead author of the study publication and professor and vice-chairman of research in Indiana University School of Medicine's Department of Neurology. "Throughout the course of Alzheimer's disease, caregivers are usually the first to notice changes in cognition. When a loved one notices the disease has gotten worse, it is important that they speak with a doctor about these changes and consider other treatments."  Read more: mynews3.com

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Anti-diabetic potential of lupin 

The potential anti-diabetic activity of a glycoprotein found in lupin seeds may be due to its ability to pass through the gut barrier, where it may have bioactive properties – according to new research.  Read more: nutraingredients.com

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Alzheimer's: identifying the genes

(new genes)

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Scientists have found three new major genetic links to Alzheimer's, affecting up to 20 percent of people with the brain-wasting disease, and said on Sunday it was the most significant such discovery in 15 years.

Two large studies found that the three new genes join the better-known APOE4 gene as significant risk factors for the most common cause of dementia.

"If we were able to remove the detrimental effects of these genes through treatments, we could reduce the proportion of people developing Alzheimer's by 20 percent," Julie Williams, a professor of Neuropsychological Genetics at Britain's Cardiff University, told a news conference in London.

Alzheimer's disease affects more than 26 million people globally, has no cure and no good treatment. The need for effective remedies is pressing, with the number of cases forecast to go beyond 100 million by 2050.

Current drugs can only delay the symptoms endured by patients, who lose their memories, the ability to find their way around and to care for themselves.

Williams, who led one of the two studies published in Nature Genetics, said that in Britain alone, eradicating the effects of the three new genes would mean almost 100,000 people could avoid the disease.

She said the findings were the most significant genetic discoveries for Alzheimer's in the 15 years since APOE4 was found to be linked, and said drug companies had shown a keen interest in their research. Read more: canada.com

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Probiotics against stress 

The link between gut and brain may extend to reducing stress, as data from animal and human studies show a reduction in anxiety following probiotic supplementation. Read more: nutraingredients.com

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