Memantine for Alzheimer's disease
(will not stop the progression of the disease)
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Memantine is the first in one class of medicines developed to treat Alzheimer's disease. It has been available in Europe for years but was only recently approved for treating Alzheimer's disease in the United States. It works in a completely different way compared to other Alzheimer's disease medicines.
It is possible that symptoms of Alzheimer's disease may be related to an imbalance of brain chemicals—specifically glutamate—that affect learning and memory. Memantine blocks the activity of glutamate and improves moderate to severe symptoms of Alzheimer's disease. Memantine is the first medicine available that slows the late stages of Alzheimer's disease. It effectively reduces moderate to severe symptoms of memory loss and thinking problems, as opposed to other medicines that improve mild to moderate symptoms. Memantine is the only medicine available to treat more severe thinking and memory symptoms of Alzheimer's disease. But no medicine has yet been developed that can stop the damaging changes in the brain that cause personality changes and memory loss from Alzheimer's disease.
Patients with moderate to severe Alzheimer's disease who were taking cholinesterase inhibitors experienced improvement in their thinking and daily functioning when they added memantine (Namenda) to their treatment. Read more: health.com
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