A new paradigm for Alzheimer's research
(a more open-minded approach)
Please Help Support Alzheimer's Research Today!
Your Alzheimer's donation will help billions live without it.
To those concerned about health care costs and who worry about the impact of population growth and an aging population on the financial viability of health care providers, and who also remain unconvinced by the U.S. administration's math as it applies to health care [1], the continued lack of drugs to effectively treat stroke and Alzheimer's disease (AD) is a major concern.
According to 2007 data from the World Health Organization, approximately 15 million individuals suffered strokes worldwide annually, of whom one-third died and 5 million were permanently disabled. By 2050, the annual incidence of stroke is estimated to increase by 70 percent, adding further to the growing numbers of permanently disabled requiring care.
With AD, 36 million individuals are estimated to be affected in 2010 growing to 115 million by 2050 [2]. And AD caregivers in a 2 to 1 ratio add an additional 200 million or so individuals indirectly affected by the disease. These are staggering numbers by any measure — but especially for two diseases with few, if any, effective treatments despite major investments by biopharma over the past two-and-a-half decades.
The search for drugs to treat stoke proved to be a singular failure [3] as it became apparent that the dosing regimens and various animal models used preclinically bore little relationship to the clinical situation [4]. The search for drugs to treat AD has unfortunately become increasing reminiscent to that of stroke — well-funded research around dogmatic hypotheses, in this instance amyloid deposition [5] and tau hyperphosphorylation [6], animal models engineered to mechanistically reflect these hypotheses rather than AD itself, and a deluge of publications, but little to no progress in identifying effective treatments. Read more: bioworld.com
Garlic exhibits several health benefits
Problems in heart function related to diabetes may be improved by supplementation with garlic oil, according to new research with rats. Read more: nutraingredients.com
No comments:
Post a Comment