A key to predict the Alzheimer's
(neurons activity)
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Dutch researchers have discovered a possible key which might result in a medicine for Alzheimer's disease. "We have found brain cells which become extra active at a time when there are still no visible symptoms of the disease. Nevertheless, people are already ill", says brain researcher Dick Swaab. "It would be fantastic if we could simulate this activation process through medicines once the disease has progressed." The findings of the Dutch scientists, under the auspices of research institute TI Pharma, are due to be published in the reputable scientific magazine Brain.
Scientists examined the brain tissue of 49 deceased patients, in various stages of the disease. In the very earliest stage of the disease, patients did not appear to have any memory impairments or other symptoms of Alzheimer's disease. Under the microscope, however, signs of Alzheimer's are visible. Swaab: "The brain itself appears to compensate for the disease process; nearly 500 genes in the front part of the parahippocampal cortex then become extra active. These genes ensure that nerve cells are better able to communicate with each other, allowing people to continue to function well. As soon as these genes become less active, the memory impairments become apparent."
According to Swaab, this discovery is an important step on the road to finding effective medication. "We see these temporarily active genes as a pointer to a medicine. Once the disease has progressed to a more advanced stage, we can see whether we can reactivate the brain cells using medicines." Swaab adds that a medicine for Alzheimer's will only be a possibility for future generations. Read more: medilexicon.com
Scientists examined the brain tissue of 49 deceased patients, in various stages of the disease. In the very earliest stage of the disease, patients did not appear to have any memory impairments or other symptoms of Alzheimer's disease. Under the microscope, however, signs of Alzheimer's are visible. Swaab: "The brain itself appears to compensate for the disease process; nearly 500 genes in the front part of the parahippocampal cortex then become extra active. These genes ensure that nerve cells are better able to communicate with each other, allowing people to continue to function well. As soon as these genes become less active, the memory impairments become apparent."
According to Swaab, this discovery is an important step on the road to finding effective medication. "We see these temporarily active genes as a pointer to a medicine. Once the disease has progressed to a more advanced stage, we can see whether we can reactivate the brain cells using medicines." Swaab adds that a medicine for Alzheimer's will only be a possibility for future generations. Read more: medilexicon.com
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