Friday, December 31, 2010

Poor blood vessel could lead to Alzheimer's 
(it’s vital)
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It seems like every day we hear new reports on Alzheimer’s research, some promising and some discouraging. One minute you may hear encouraging news about how to prevent Alzheimer’s in the first place only to have hopes dashed  by some other body of data. One thing scientists seem to agree on however, is that once the causes of Alzheimer’s are identified finding better methods of treatment – and possibly prevention – are much more easily obtained.
Once of the more recent reports points a finger at a condition widely known in the medical community for causing cardiovascular disease.  It’s called endothelium dysfunction and it’s a problem with blood vessel linings – called endothelium – that may lead to the development of Alzheimer’s.   
In this dysfunction process the endothelium secretes protein substances that promote plaque formation in the vessels rather than the substances that prevent plaque build up.  It’s the earliest indicator of cardiovascular disease, but now scientists have learned that a poorly functioning endothelium affects the brain as well as the heart. Read more: insidershealth.com

Food for healthy blood vessels
Healthy blood vessels are important so the heart does not need to work as hard to pump blood. Flexible and elastic blood vessels keep the risk low for cardiovascular disease, strokes, and some forms of dementia in the elderly. Researchers have found some foods to be very beneficial for healthy blood vessels---and some very detrimental as well. Read more: ehow.com



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Thursday, December 30, 2010

People at high risk for Alzheimer's disease develop abnormal brain function 
(before the appearance of amyloid plaques)
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Your Alzheimer's donation will help billions live without it.

Researchers at Washington University School of Medicine in St. Louis report in the Dec. 15 issue ofThe Journal of Neuroscience that these patients had a particular form of the apolipoprotein E (APOE) gene called APOE4. The findings suggest that the gene variant affects brain function long before the brain begins accumulating the amyloid that will eventually lead to dementia.
"We looked at a group of structures in the brain that make up what's called the default mode network," says lead author Yvette I. Sheline, MD. "In particular, we are interested in a part of the brain called the precuneus, which may be important in Alzheimer's disease and in pre-Alzheimer's because it is one of the first regions to develop amyloid deposits. Another factor is that when you look at all of the structural and functional connections in the brain, the most connected structure is the precuneus. It links many other key brain structures together."
The research team conducted functional MRI scans on 100 people whose average age was 62. Just under half of them carried the APOE4 variant, which is a genetic risk factor for late-onset Alzheimer's disease. Earlier PET scans of the study subjects had demonstrated that they did not have amyloid deposits in the brain. Amyloid is the protein that makes up the senile plaques that dot the brains of Alzheimer's patients and interfere with cognitive function.
Participants in the study also underwent spinal puncture tests that revealed they had normal amyloid levels in their cerebrospinal fluid. Read more: sciencedaily.com

Nitrate in beetroot juice increases tolerance to exercise
A new study claims that the positive effects of beetroot juice on heart and the body’s response to exercise are entirely down to its high nitrate content. Read more: nutraingredients.com

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