Higher levels of HDL cholesterol - decreased risk of Alzheimer's disease
(above 55 mg/dl)
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A low level of high-density lipoproteins (HDL), commonly known as "good" cholesterol, may raise the risk of developing Alzheimer's disease say US researchers, who caution their findings still need to be confirmed by other studies. The researchers, from Columbia University College of Physicians & Surgeons, New York, NY, report their investigation in a study published in the December issue of Archives of Neurology, a JAMA/Archives journal.
Low levels of high-density lipoproteins (HDL), a well-known risk factor for heart disease, are common in the US, said lead author Dr Christiane Reitz, assistant professor of neurology in the Sergievsky Center and Taub Institute at the University, in a press statement. She and her colleagues also wrote in their background information that: "Dyslipidemia [high total cholesterol and triglycerides] and late-onset Alzheimer's disease are highly frequent in western societies. More than 50 percent of the US adult population has high cholesterol. About 1 percent of people age 65 to 69 years develop Alzheimer's disease, and the prevalence increases to more than 60 percent for people older than 95 years," they added.
Previous studies of HDL and Alzheimer's risk have either found no link or their findings have been unclear, but their new study followed participants for longer, resulting in a more accurate account of the numbers who went on to develop Alzheimer's disease, the researchers told the press. For this study, for an average of four years, they followed 1130 elderly people living in northern Manhattan. The participants came from a random sampling of Medicare recipients and were aged 65 and over. None had a history of dementia or cognitive impairment when they joined. To collect their data, Reitz and colleagues studied medical, neurological and neuropsychological evaluations. They assigned a diagnosis of "probable" Alzheimer's disease when onset of dementia could not be explained by any other disorder and a diagnosis of "possible" Alzheimer's disease when the most likely cause of dementia was Alzheimer's disease but there was evidence that other disorders could have contributed to the dementia, such as stroke or Parkinson's disease. Read more: medilexicon.com
Low levels of high-density lipoproteins (HDL), a well-known risk factor for heart disease, are common in the US, said lead author Dr Christiane Reitz, assistant professor of neurology in the Sergievsky Center and Taub Institute at the University, in a press statement. She and her colleagues also wrote in their background information that: "Dyslipidemia [high total cholesterol and triglycerides] and late-onset Alzheimer's disease are highly frequent in western societies. More than 50 percent of the US adult population has high cholesterol. About 1 percent of people age 65 to 69 years develop Alzheimer's disease, and the prevalence increases to more than 60 percent for people older than 95 years," they added.
Previous studies of HDL and Alzheimer's risk have either found no link or their findings have been unclear, but their new study followed participants for longer, resulting in a more accurate account of the numbers who went on to develop Alzheimer's disease, the researchers told the press. For this study, for an average of four years, they followed 1130 elderly people living in northern Manhattan. The participants came from a random sampling of Medicare recipients and were aged 65 and over. None had a history of dementia or cognitive impairment when they joined. To collect their data, Reitz and colleagues studied medical, neurological and neuropsychological evaluations. They assigned a diagnosis of "probable" Alzheimer's disease when onset of dementia could not be explained by any other disorder and a diagnosis of "possible" Alzheimer's disease when the most likely cause of dementia was Alzheimer's disease but there was evidence that other disorders could have contributed to the dementia, such as stroke or Parkinson's disease. Read more: medilexicon.com
Creatine may beef up brain function
Supplements of creatine, most commonly associated with sports nutrition, may boost cognitive function in vegetarians, a group at risk of low creatine levels, says a new study. Read more: nutraingredients.com
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