The importance of impaired clearance of amyloid beta from the brain
(slow clearance of amyloid protein)
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There has previously been speculation that an imbalance of amyloid production and clearance causes Alzheimer’s disease. However, in this study people with Alzheimer’s disease were found to clear the protein 30% slower than unaffected individuals. This suggests that slower clearance of the protein, rather than overproduction, may be a potential reason for the accumulation of protein in the brain in Alzheimer’s disease.
As the researchers point out, this was a small study that cannot say whether impaired amyloid beta clearance is a cause or consequence of Alzheimer’s disease. However, this is exciting research that highlights the importance of amyloid beta clearance in Alzheimer’s disease and provides clear targets for future research. Where did the story come from?The study was carried out by researchers from Washington University, and was funded by The US National Institutes of Health, and grants from the Eli Lilly pharmaceutical company, The Knight Initiative for Alzheimer Research, the James and Elizabeth McDonnell Fund, and an Anonymous Foundation charitable organisation.
The researchers found that the rate of amyloid beta production did not differ between the people with Alzheimer’s disease and those without. However, the average clearance rate of two forms of amyloid beta, called Aß40 and Aß42, was slower in the people with Alzheimer’s disease than in unaffected control subjects. The people with Alzheimer’s disease cleared 5.2 to 5.3% of amyloid beta per hour, whereas the control group cleared between 7 to 7.6% of amyloid beta (p=0.03). Read more: medicaldaily.com
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