Protein restores memory in Alzheimer's model
(CREB-binding protein)
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Scientists at the UT Health Science Center San Antonio restored learning and memory in an Alzheimer's disease mouse model by increasing a protein called CBP. Salvatore Oddo, Ph.D., of the university's Department of Physiology and Barshop Institute for Longevity and Aging Studies, said this is the first proof that boosting CBP, which triggers the production of other proteins essential to creating memories, can reverse Alzheimer's effects. "One way by which CBP could work is by setting off a domino effect among proteins that carry signals from the synapse to the nucleus of the neuron," Dr. Oddo said. "Getting signals to the nucleus is necessary for long-term memory." The research team engineered a harmless virus to deliver CBP to the hippocampus in the temporal lobe. The hippocampus is the brain's key structure for learning and memory. At 6 months of age, when the CBP delivery took place, the specially bred mice were at the onset of Alzheimer's-like deficits. Learning and memory were evaluated in a water maze that required mice to remember the location of an exit platform. The mice treated with CBP were compared to diseased mice that received only placebo and to normal, healthy control mice. Read more: medilexicon.com
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