Healthy aging could help unravel the processes that lead to neurodegeneration
(normal aging)
(normal aging)
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Recent studies have identified changes in how genes are read, or expressed, in the brain either during aging or with neurodegenerative disease. However, no previous study had directly compared gene expression changes in healthy aging with those in diseased individuals.
In this report, an international team of researchers analyzed and compared changes in gene expression associated with aging and disease in a region of the brain known to be affected in both Alzheimer's and FTLD. Comparing samples from healthy individuals ranging from 16 to 102 years old with samples from diseased individuals, the investigation uncovered striking similarity in the changes in gene expression patterns associated with aging and the neurodegenerative diseases.
"Surprisingly, these [diseased] samples contained the same aging-related changes as healthy individuals over the age of 80," said Dr. Jernej Ule of the MRC Laboratory of Molecular Biology, senior author of the study.
"Aging-related changes were apparent in the diseased individuals as young as 50 years," noted Dr. James Tollervey of the MRC Laboratory of Molecular Biology, the first author of the study, "roughly 25 years before we would expect to see similar changes in healthy individuals.". Continue to read: eurekalert.org
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