Alzheimer's risk and surgery
(Celastrol was seen to reduce inflammation)
(Celastrol was seen to reduce inflammation)
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Tests carried out on mice have revealed changes in their brains, similar to those observed in humans with dementia, when the animals are operated on. The researchers suspect the same effect could occur in humans after surgical procedures and are now to start a new study to further explore the theory. Many doctors already suspect there may be a link between surgery and the onset of Alzheimer's.
Previous studies have suggested that between 10 and 30 per cent of elderly people who undergo surgery suffer memory problems afterwards, but it has not been established whether these are a short-term response to physical trauma, or the beginnings of dementia. Cognitive problems, ranging from memory loss to delirium, have been found most commonly when elderly people have undergone heart surgery, but also following other operations. It is not known if the procedures themselves, or the body's response to major trauma, spark changes in the brain. The latest research, conducted at Imperial College London and due to be published in the journal Critical Care Medicine next month, shows that the brains of mice who underwent a surgical procedure showed the presence of protein "tangles" in the brain which are associated with Alzheimer's disease in humans. Read more: telegraph.co.uk
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