Rheumatoid arthritis is a negative risk factor for Alzheimer's disease
(50%-60% reduction in the amount of amyloid in the brain)
(50%-60% reduction in the amount of amyloid in the brain)
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A protein produced in arthritis “appears to protect against the development of Alzheimer's disease,” BBC News has reported. Its website says that US research on mice has discovered that a protein called GM-CSF, produced in rheumatoid arthritis, may trigger the immune system to destroy the protein plaques found in Alzheimer’s. This research used mice that had been genetically engineered to have a condition similar to Alzheimer’s. It found that these mice performed better in tests of memory and learning after they had been given a GM-CSF injection for 20 days. The protein also helped normal mice to improve their performance in the tests. After the injections, the mouse brains also contained increased levels of microglial cells, types of cells that engulf debris and foreign organisms. It is possible that these microglial cells could combat the build-up of amyloid proteins that characterise Alzheimer’s disease. The findings help to further the understanding of how rheumatoid disease may offer some protection against the development of Alzheimer’s. However, it remains to be seen whether this research could be a first step towards investigating GM-CSF as a potential treatment, which will now need further testing.
This was research in mice, which aimed to further the understanding of why people with rheumatoid arthritis (RA) appear to have a reduced risk of Alzheimer’s disease (AD). It has often been assumed that this reduced risk was due to the use of anti-inflammatory drugs to treat RA, but this study investigated whether certain immune system proteins that have increased activity in RA could have an influence on Alzheimer’s risk. The proteins of interest were macrophage (M-CSF), granulocyte (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Animal studies can provide valuable information on disease processes and the factors that may be involved in the development of a disease. However, mice are different from humans and the findings in this exploratory mouse model of AD may not be directly transferable to the disease in humans. Read more: lep.co.uk
This was research in mice, which aimed to further the understanding of why people with rheumatoid arthritis (RA) appear to have a reduced risk of Alzheimer’s disease (AD). It has often been assumed that this reduced risk was due to the use of anti-inflammatory drugs to treat RA, but this study investigated whether certain immune system proteins that have increased activity in RA could have an influence on Alzheimer’s risk. The proteins of interest were macrophage (M-CSF), granulocyte (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Animal studies can provide valuable information on disease processes and the factors that may be involved in the development of a disease. However, mice are different from humans and the findings in this exploratory mouse model of AD may not be directly transferable to the disease in humans. Read more: lep.co.uk
Exercise Can Make You Feel More Full
By a simple food-in/energy-out model, a run on the treadmill or swim in the pool should make you want to eat more. But recent findings have suggested that exercise can actually help to slow overeating. And a new study presents evidence that the body's physiologic response to exercise can help retune the nervous system's cues and make the body feel less hungry, rather than more so. Read more: scientificamerican.com
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