Metformin reduces the risk of dementia
(diabetes drug)
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Scientists in Dundee have discovered that the drug metformin helps prevent the formation of a key brain abnormality linked to the disease. Alzheimer's charities said further research was needed to see whether metformin really could help patients. Because the drug's safety is already proven it could be relatively easy to turn it into an Alzheimer's treatment.
Metformin, which is taken in pill form, belongs to a class of drugs called biguanides that help regulate blood sugar levels. It is widely used by people with Type 2 diabetes and has few side effects. Experiments on mouse brain cells showed the drug affects the "tau tangles" - filaments of toxic protein that build up in the neurons of Alzheimer's sufferers. Metformin was shown to activate a natural enzyme that in turn reduced the tangle formation.
The international team of researchers was co-led by Dr Susan Schweiger from the University of Dundee, who wrote about the discovery in the journal Proceedings of the National Academy of Sciences. Read more: bbc.co.uk
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