Alzheimer's drugs hurt brain?
(the impacts of beta peptide structures prior to amyloid formation)
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Drugs being investigated for Alzheimer's disease may be causing further neural degeneration and cell death, calling for a change in the way Alzheimer's medications are developed, according to results published in Proceedings of the National Academy of Sciences.
Alzheimer's and other neurodegenerative diseases are thought to be caused by amyloids composed of misfolded beta peptides. The accumulation of these can result in the creation of amyloid plaques in the brain, causing cell death. Higher levels of amyloid beta peptides lead to "earlier onset or more severe systems of Alzheimer's disease" said Urbanc, and are believed to be the primary cause of the disease.
Current drug candidates for Alzheimer's disease target these amyloid structures, either by inhibiting the cutting of beta peptides to prevent the formation of amyloids or by creating truncated forms of the beta peptides that do not form amyloids. However, in 2007, one such drug failed Phase III clinical trials because it did not show any cognitive improvement, suggesting that something other than amyloid plaques may be to blame for Alzheimer's disease. Read more: The Scientist
Gut bacteria are what we eat
Gut microbes, which help humans degrade otherwise indigestible plant material, acquire some crucial digestive enzyme genes from the bacteria in the food we eat, according to a study published this week in Nature. This new finding provides an example of horizontal gene transfer by which diet can influence the genetic diversity and functionality of the human gut microbiome. In a neat confluence of human history, stomach bacteria and food, researchers have found that the intestinal microbes of Japanese people may be souped up for eating seaweed. Read more: wired.com
What the World Eats ~~~~~~~~~~~ Georgian Cuisine
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