The identification of new genes associated with Alzheimer's
( new pathways that merit further study )
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Two new reports in Nature Genetics detail the discovery of five new pathways for detecting Alzheimer's disease, the memory-stealing brain illness that is especially prevalent among the elderly.
Previous research had identified five genes linked to Alzheimer's disease, or AD. The combined efforts of an international consortium of researchers has raised those known genetic markers to 10."We've really doubled the number of clues we have about late-onset AD. We have a lot left to do to complete the story of AD genetics, but this is a big step," said Professor Gerard D. Schellenberg of the University of Pennsylvania, lead researcher for one of the studies. "Almost as important as the genes discovered is the fact that a large number of investigators are working together to solve the genetics of AD," Schellenberg said. "We just started an international consortium, IGAP (International Genomics of Alzheimer's Project), so all the groups that produced both papers are now collaborating." IGAP includes scientists from four university research groups and creates a shared database that includes genetic information for more than 40,000 patients. "Of course, I am a bit biased, but I think this is a big deal," Schelleberg said.
In addition, genetic studies can help researchers understand the pathogenic mechanisms that begin in the brain long before symptoms appear, eventually destroying large parts of the brain and causing the complete loss of cognitive abilities. One primary goal of genetic studies is to help identify who is likely to develop the disease, which will be important when preventive measures become available.
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