Probing how proteins clog cell motors in Alzheimer's
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Beta amyloid — the protein associated with Alzheimer’s disease — is responsible for clogging several cell-transport motors necessary for cell division.
This blockage leads to the abnormal cell division and defective neurons associated with the disease, according to researchers at the University of South Florida.
The protein may cause neurons to malfunction, leading to the memory loss that accompanies Alzheimer’s progression, said scientists at the USF Health Byrd Alzheimer’s Institute, the Florida Alzheimer’s Disease Research Center, and Indiana University, who conducted the study using human cell cultures and frog egg extracts.
“It’s kind of like throwing sand in the gears of the cell’s transport machinery,” said first author Sergiy Borysov, Ph.D.
“It keeps the wheels from moving, which interferes with the cell division cycle and ultimately leads to the production of degeneration-prone neurons seen in the Alzheimer’s disease brain.”
The findings help further define how interference with cell division could result in a cascade of events that contributes to the development of Alzheimer’s. Read more: psychcentral.com
This blockage leads to the abnormal cell division and defective neurons associated with the disease, according to researchers at the University of South Florida.
The protein may cause neurons to malfunction, leading to the memory loss that accompanies Alzheimer’s progression, said scientists at the USF Health Byrd Alzheimer’s Institute, the Florida Alzheimer’s Disease Research Center, and Indiana University, who conducted the study using human cell cultures and frog egg extracts.
“It’s kind of like throwing sand in the gears of the cell’s transport machinery,” said first author Sergiy Borysov, Ph.D.
“It keeps the wheels from moving, which interferes with the cell division cycle and ultimately leads to the production of degeneration-prone neurons seen in the Alzheimer’s disease brain.”
The findings help further define how interference with cell division could result in a cascade of events that contributes to the development of Alzheimer’s. Read more: psychcentral.com
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