Brain rust a cause of Alzheimer's
(reverse brain damage)
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Australian scientists have made a significant advance in the understanding of Alzheimer's disease, a condition they describe as an accumulation of brain "rust". An imbalance in the metals needed for healthy brain function has been found at the root of the degenerative disease which afflicts 10 per cent of people aged over 60.
University of Melbourne Professor of Pathology Ashley Bush and his research colleagues have traced the imbalance to the brain's improper and related processing of zinc and iron.Their research is detailed in a paper to be published in the prestigious international journal Cell later this month. "The brain in Alzheimer's disease is a catastrophe, and it is very hard to pinpoint what went wrong first," Prof Bush told AAP on Monday. "This (research) really unravels quite a big series of knots and highlights a particular sequence involving these two metals. "... It is the most in-depth series of biochemical discoveries about Alzheimer's disease and its causes to date."
The research focused on the complex relationship between amyloid precursor protein (APP) and its breakdown product amyloid, along with the zinc and iron. Prof Bush said as zinc was seen to accumulate in amyloid it blocked the APP from performing its critical, and previously unknown, job of exporting iron out of the brain's neurons. This led to a build-up of iron "in the grey matter", he said, resulting in oxidative stresses that could kill off neurons.
So could you say the loss of mental function in an Alzheimer's patient is caused by rust in their brain? "In a chemical sense, you can," Prof Bush said. "That's the kind of chemistry that is going on in the brain and, similar to actual rust, it involves an abnormal combustion of oxygen with iron. "The brain is an unusual organ in that it has very high concentrations of metals which it uses for its electrical chemistry." Read more: news.smh.com.au
NEVER trust labels on food
No artificial colours or flavours. No hydrogenated fat, it read in large letters on the front. Reassured, I popped the packet in our trolley. But back in the comfort of home, I took a closer look (and I needed my reading glasses for the small print) and pretty quickly concluded that I’d been had. Read more: dailymail.co.uk
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