Thursday, September 2, 2010

 Protein that Fuels Alzheimer's Disease
(understanding Alzheimer's disease)  
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Researchers at the Fisher Center for Alzheimer's Disease Research laboratory today published "Gamma-secretase Activating Protein is a Therapeutic Target for Alzheimer's Disease" in Nature online.  Drs. Gen He (lead author) and Paul Greengard have discovered a protein that stimulates the production of beta-amyloid, and therefore represents a major new advance in Alzheimer's disease research.
The protein, called gamma-secretase activating protein (gSAP), is expected to become a major target for anti-amyloid drugs that inhibit the brain's ability to produce toxic beta amyloid in Alzheimer's disease.  Beta-amyloid is a substance found in the brain that becomes toxic in Alzheimer's disease and is responsible for most of the devastating symptoms of the disease.  The researchers also discovered that gSAP is a target of the anti-cancer drug, Gleevec, which Fisher scientists previously showed could lower beta-amyloid levels in the brain.  The new study showed that Gleevec lowers beta-amyloid production by binding to gSAP and preventing it from activating an enzyme called gamma-secretase, which is responsible for producing beta-amyloid.  In addition, the researchers showed that the inhibition of gSAP is not toxic to nerve cells, unlike many other experimental beta-amyloid inhibitor drugs that produce severe toxic reactions.  Hence, gSAP holds the promise of discovering highly specific anti-beta-amyloid drugs that will be safe to patients. Read more: wdtn.com
TODAY'S PHOTO    

Link between vitamin D intake and protection from cancer
Giving fish oil capsules to patients with a heart condition could save 10,000 lives a year claim doctors. A review revealed omega-3 supplements prevented the deaths of almost one in ten patients with heart failure. Read more
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