Sunday, September 12, 2010

 Preventing traffic jam in the brain

important to develop new strategies

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Amyloid beta proteins, widely thought to cause Alzheimer's disease (AD), block the transport of vital cargoes inside brain cells. Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that reducing the level of another protein, tau, can prevent Amyloid beta from causing such traffic jams.

Neurons in the brain are connected to many other neurons through long processes called axons. Their functions depend on the transport of diverse cargoes up and down these important pipelines. Particularly important among the cargoes are mitochondria, the energy factories of the cell, and proteins that support cell growth and survival. Amyloid beta (Aβ) proteins, which build up to toxic levels in the brains of people with AD, impair the axonal transport of these cargoes.

"We previously showed that suppressing the protein tau can prevent Aβ from causing memory deficits and other abnormalities in mouse models of AD," explained Lennart Mucke, MD, GIND director and senior author of the study. "We wondered whether this striking rescue might be caused, at least in part, by improvements in axonal transport."

The scientists explored this possibility in mouse neurons grown in culture dishes. Neurons from normal mice or from mice lacking one or both tau genes were exposed to human Aβ proteins. The Aβ slowed down axonal transport of mitochondria and growth factor receptors, but only in neurons that produced tau and not in neurons that lacked tau. In the absence of the Aβ challenge, tau reduction had no effect on axonal transport. 
 Read more: medilexicon.com







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