Searching for an Alzheimer's miracle
(condition worsened while he was taking the Lilly drug)
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Scientists are still unsure what causes Alzheimer's disease and how best to attack it. Here are two leading theories:
Amyloid plaques
One of the hallmarks of Alzheimer’s disease is the accumulation of sticky plaques between nerve cells in the brain. Amyloid is a general term for protein fragments that the body produces normally. Amyloid beta is a protein fragment snipped from an amyloid precursor protein. In a healthy brain, these protein fragments are broken down and eliminated. In a patient with Alzheimer’s disease, the fragments accumulate to form hard, insoluble plaques. According to the amyloid hypothesis, the best way to attack the disease is to prevent the buildup of amyloid beta or to clear it out of the brain once it forms.
Neurofibrillary tangles
These are twisted fibers found inside the brain's cells. These tangles consist primarily of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer's disease, however, the tau protein is abnormal, and the microtubule structures collapse. Under the tau hypothesis, the best way to attack the disease is to block the tau protein that accumulates in dead and dying nerve cells. Read more: indystar.com
Amyloid plaques
One of the hallmarks of Alzheimer’s disease is the accumulation of sticky plaques between nerve cells in the brain. Amyloid is a general term for protein fragments that the body produces normally. Amyloid beta is a protein fragment snipped from an amyloid precursor protein. In a healthy brain, these protein fragments are broken down and eliminated. In a patient with Alzheimer’s disease, the fragments accumulate to form hard, insoluble plaques. According to the amyloid hypothesis, the best way to attack the disease is to prevent the buildup of amyloid beta or to clear it out of the brain once it forms.
Neurofibrillary tangles
These are twisted fibers found inside the brain's cells. These tangles consist primarily of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer's disease, however, the tau protein is abnormal, and the microtubule structures collapse. Under the tau hypothesis, the best way to attack the disease is to block the tau protein that accumulates in dead and dying nerve cells. Read more: indystar.com
Probiotic bacteria may affect gene activity and the cellular reactions they control in the human intestine, a study has revealed for the first time. Read more: nutraingredients.com
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